Table 2.
Between-group differences in primary and secondary outcomes in PTR and PR groups. Intention-to-treat principle
| Between-group differences from baseline (95% CI) | ||||
| PR-PTR (unadjusted) | PR-PTR (adjusted) | |||
| End rehabilitation† | 22 weeks from baseline‡ | End rehabilitation† | 22 weeks from baseline‡ | |
| Primary outcome | ||||
| 6MWD, min | 6.3 (−9.8 to 22.5) | −11.0 (−34.4 to 12.4) | 8.3 (−7.7 to 24.3) | −3.9 (−27.9 to 19.9) |
| Secondary outcomes | ||||
| 30sec-STS, reps | 0.5 (−0.6 to 1.5) | 0.4 (−0.7 to 1.4) | 0.5 (−0.6 to 1.5) | 0.5 (−0.6 to 1.6) |
| CAT, points | 1.4 (−0.1 to 3.0) | −0.5 (−2.6 to 1.5) | 1.6 (0.1 to 3.3)* | −0.2 (−2.1 to 1.8) |
| HADS | ||||
| Anxiety, points | 1.1 (0.1 to 2.1)* | 0.2 (−0.9 to 1.4) | 1.2 (0.2 to 2.3)* | 0.4 (−0.8 to 1.6) |
| Depression, points | 0.7 (−0.1 to 1.5) | −0.2 (−1.3 to 1.0) | 0.9 (0.1 to 1.7)* | −0.2 (−1.3 to 1.0) |
| EQ-5D-VAS, points | −0.2 (−6.4 to 5.9) | 0.8 (−5.8 to 7.5) | −0.2 (−6.2 to 5.9) | 1.6 (−5.1 to 8.3) |
| CCQ | ||||
| Function, points | 0.1 (−0.2 to 0.5) | 0.1 (−0.2 to 0.5) | 0.1 (−0.2 to 0.5) | 0.2 (−0.2 to 0.5) |
| Mental, points | 0.1 (−0.3 to 0.6) | −0.1 (−0.4 to 0.3) | 0.3 (−0.2 to 0.7) | 0.1 (−0.3 to 0.5) |
| Symptoms, points | 0.2 (−0.1 to 0.5) | 0.1 (−0.3 to 0.5) | 0.2 (−0.1 to 0.5) | 0.1 (−0.2 to 0.5) |
| Total, points | 0.2 (−0.1 to 0.4) | 0.1 (−0.2 to 0.3) | 0.2 (−0.1 to 0.5) | 0.1 (−0.1 to 0.4) |
| PAL | ||||
| Steps per day | −283 (−845 to 278) | −302 (−1035 to 419) | −436 (−1010 to 138) | −103 (−886 to 597) |
| Sedentary, min | 9.4 (−35.2 to 51.3) | 8.6 (−53.8 to 36.6) | 7.7 (−49.0 to 52.2) | 14.6 (−32.5 to 58.5) |
| Active, min | −9.4 (−51.3 to 35.4) | −8.6 (−36.6 to 53.8) | −7.7 (−52.2 to 49.0) | −14.6 (−58.5 to 32.5) |
Data are mean difference (95% CI).
*P value for group mean change differences <0.05.
†Complete observations (n) used for the likelihood estimate from end of rehabilitation to baseline (total): 6MWD: (115); 30sec-STS: (115); CAT: (119); HADS: (110); EQ-5d-VAS: (119); CCQ: (119); PAL: (59).
‡Complete observations (n) used for the likelihood estimate from 22 weeks’ follow-up from baseline to baseline (total): 6MWD: (95); 30sec-STS: (95); CAT: (106); HADS: (100); EQ-5d-VAS: (104); CCQ: (106); PAL: (55).
CAT, COPD Assessment Test; CCQ, COPD Clinical Questionnaire; EQ-5D, EuroQol 5-Dimension Questionnaire; HADS, Hospital Anxiety and Depression Scale; 6MWD, 6 min walk distance; PAL, physical activity level; PR, pulmonary rehabilitation; PTR, pulmonary tele-rehabilitation; 30sec-STS, 30 s sit-to-stand test; VAS, Visual Analogue Scale.