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. 2020 Mar 4;91(5):483–492. doi: 10.1136/jnnp-2019-322138

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Percent change in brain volume (re-baselined from 6 months) by time point (FAS). Data are expressed as adjusted mean±95% CI. n, number of patients included in each analysis. EOS is defined as the last assessment taken on or before the final study phase visit date. ^aObtained from fitting an ANCOVA model adjusted for treatment, region, pubertal status (the stratification factor in IVRS) and 6-month baseline normalised brain volume as covariates. ANCOVA, analysis of covariance; EOS, end of the study; FAS, full analysis set; IFN, interferon; IVRS, interactive voice response system.