Table 3.
Identified AAT binding partners
| AAT binding partner | P value | Confidence score | Peptide count |
| Complement C3 | 8.88×1015 | 370.28 | 37 |
| Complement C4-A | 1.00×1030 | 340.29 | 34 |
| Fibronectin | 8.88×1015 | 300.28 | 30 |
| Apolipoprotein B-100 | 3.44×1014 | 250.22 | 25 |
| ITIH4 | 1.00×1030 | 200.33 | 20 |
| Serum albumin | 1.55×1014 | 190.27 | 19 |
| Apolipoprotein A-I | 6.71×1010 | 140.30 | 14 |
| Fibrinogen alpha chain | 1.55×1014 | 140.30 | 14 |
| Prothrombin | 5.55×1015 | 110.24 | 11 |
| Ig mu chain C region | 1.19×1011 | 90.20 | 9 |
Two-stage purification of AAT from plasma using size exclusion chromatography and co-immunoprecipitation (n=6), followed by identification of AAT binding partners by MS. The 10 highest scoring proteins identified as AAT binding partners are listed in descending order of confidence score and peptide count.
AAT, alpha-1 antitrypsin; ITIH, inter-alpha-trypsin inhibitor heavy chain.