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. 2019 Nov 8;57(5):289–295. doi: 10.1136/jmedgenet-2019-106277

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Cohesin and cell cycle. Cohesin is loaded onto chromosomes prior to DNA replication by a binary protein complex formed by NIPBL and MAU2. ESCO (1 and 2) are acetyltransferases that establish sister chromatid cohesion during DNA replication by promoting the acetylation of a pair of lysine residues within SMC3. Pds5 (A and B) has a cohesive effect on cohesin, while having the opposite impact when associated with Wapl. Finally, HDAC8, a histone deacetylase, targets SMC3 permitting cohesin recycling.