Table 1. Clinical and Laboratory Characteristics of Included Patients.
Fibrosis Group (n = 14) | Non-Fibrosis Group (n = 18) | P | |
---|---|---|---|
Clinical characteristic | |||
Age (year) | 54.0 (49.0–65.3) | 37.0 (30.5–52.5) | 0.008 |
Male: female ratio | 12:2 | 10:8 | 0.124 |
Comorbidity | |||
Diabetes | 1 (7.1) | 1 (5.6) | > 0.050 |
Hypertension | 4 (28.6) | 0 (0) | 0.028 |
Cardiac disease | 1 (7.1) | 1 (5.6) | > 0.050 |
Chronic obstructive pulmonary disease | 1 (7.1) | 0 (0) | 0.437 |
Signs and symptoms | |||
Fever | 14 (100) | 13 (72.2) | 0.052 |
Dyspnea | 6 (42.9) | 1 (5.6) | 0.027 |
Cough | 6 (42.9) | 9 (50.0) | 0.735 |
Fatigue | 7 (50.0) | 7 (38.9) | 0.721 |
Muscle ache | 5 (35.7) | 3 (16.7) | 0.252 |
Diarrhea | 0 (0) | 2 (11.1) | 0.492 |
Respiratory rate (breaths per min) | 20.0 (18.8–27.8) | 18.5 (18.0–20.0) | 0.026 |
Laboratory examinations | |||
White blood cell count (x109/L) | 3.8 (2.8–5.4) | 4.0 (2.9–4.4) | 0.687 |
Lymphocyte count (x109/L) | 0.6 (0.4–0.9) | 1.1 (0.8–1.3) | 0.003 |
Lactic dehydrogenase (U/L) | 289.0 (179.0–428.5) | 180.0 (148.5–191.0) | 0.014 |
Creatine kinase (U/L) | 112.0 (68.0–203.5) | 62.0 (51.5–114.5) | 0.031 |
C-reactive protein (mg/L) | 53.4 (29.6–111.2) | 10.0 (5.2–23.6) | 0.002 |
Alanine transaminase (U/L) | 52.0 (31.0–142.0) | 23.5 (12.0–39.0) | 0.021 |
Creatinine (μmol/L) | 81.2 (73.1–94.8) | 69.1 (61.5–80.3) | 0.029 |
Interleukin-6 (pg/mL) | 79.7 (10.5–98.3) | 11.2 (4.4–19.2) | 0.040 |
Treatment | |||
Pulsed steroid therapy | 11 (78.6) | 10 (55.6) | 0.266 |
Days of pulsed steroid therapy | 11.0 (8.0–13.0) | 5.0 (3.0–6.3) | < 0.001 |
Antiviral therapy | 14 (100) | 18 (100) | - |
Days of antiviral therapy | 12.0 (9.5–14.8) | 6.5 (5.0–12.0) | 0.012 |
Others | |||
Length of hospital stay (day) | 19.5 (11.5–21.8) | 10.0 (6.0–15.3) | 0.001 |
Intensive care unit admission | 5 (35.7) | 0 (0) | 0.010 |
Days from illness onset to initial CT scan | 5.5 (3.0–7.3) | 2.5 (1.0–5.3) | 0.039 |
Days from illness onset to worst CT scan | 11.0 (7.0–15.0) | 9.5 (6.5–11.0) | 0.042 |
Days after discharge to latest follow-up CT scan | 9.0 (7.0–11.0) | 9.0 (7.8–11.3) | - |
Data are median (interquartile range) or n (%).