Table 4. Meta-Regression Analyses Stratified by Multiple Variables.

Variable	No. of Studies	Category	Sensitivity		Specificity		LRT Chi-Square	P (Joint Model)
			Pooled Value (95% CI)	P	Pooled Value (95% CI)	P
Method to set threshold of LCC	10	ROC curve	0.81 (0.77–0.85)	0.073	0.67 (0.59–0.75)	0.685	3.91	0.14
	3	Others*	0.71 (0.62–0.79)		0.70 (0.56–0.84)
LCC cutoff value	10	> 10 mm	0.78 (0.73–0.84)	0.834	0.67 (0.59–0.75)	0.777	0.14	0.93
	3	≤ 10 mm	0.80 (0.70–0.90)		0.69 (0.55–0.84)
	6	> 12 mm	0.79 (0.72–0.86)	0.825	0.69 (0.59–0.79)	0.639	0.26	0.88
	7	≤ 12 mm	0.78 (0.72–0.85)		0.66 (0.56–0.76)
LCC measurement method	9	Curvilinear	0.80 (0.75–0.85)	0.146	0.69 (0.61–0.77)	0.445	12.18	< 0.01
	3	Linear	0.72 (0.60–0.83)		0.61 (0.45–0.77)
Prevalence of biopsy	4	≥ 75.4%†	0.74 (0.67–0.82)	0.278	0.71 (0.60–0.82)	0.78	88.2	< 0.01
Gleason score (≥ 7)	3	< 75.4%†	0.80 (0.73–0.88)		0.73 (0.62–0.85)
Magnet strength	8	3T	0.78 (0.72–0.84)	0.589	0.68 (0.59–0.77)	0.811	0.54	0.76
	5	1.5T	0.81 (0.73–0.89)		0.66 (0.54–0.78)
Experience of MR readers	6	≥ 10 years	0.79 (0.74–0.84)	0.613	0.64 (0.57–0.72)	0.016	52.61	< 0.01
	4	< 10 years	0.81 (0.75–0.88)		0.80 (0.72–0.88)
Endorectal coil	5	Used	0.72 (0.66–0.77)	0.001	0.63 (0.51–0.75)	0.344	10.37	0.01
	8	Not used	0.83 (0.79–0.87)		0.70 (0.62–0.79)
Publication year	11	After 2000	0.80 (0.75–0.85)	0.354	0.69 (0.62–0.76)	0.303	2.04	0.36
	2	Before 2000	0.72 (0.57–0.88)		0.58 (0.38–0.77)

^*10 mm as stated by PI-RADS v2 guideline in one study (26), and unclear explanation in two (31,33), ^†Median value of all included studies. CI = confidence interval, LRT = likelihood-ratio test, MR = magnetic resonance