TABLE 2.
PD characteristics
| Variable | GBA PD BL Visit, N = 80 | LRRK2PD BL Visit, N = 158 | sPD Year 2 Visit, N = 361 | P Values | ||
|---|---|---|---|---|---|---|
| GBA vs. LRRK2 | GBA vs. sPD | LRRK2 vs. sPD | ||||
| MDS-UPDRS total score, off | 0.1027 | 0.7649 | 0.0078 | |||
| Mean (SD) | 42.2 (15.6) | 37.3 (19.4) | 42.8 (16.8) | |||
| Missing | 19 | 45 | 92 | |||
| MDS-UPDRS part I | 0.6767 | 0.8107 | 0.7778 | |||
| Mean (SD) | 7.8 (5.2) | 8.1 (6.0) | 7.7 (5.0) | |||
| Missing | 0 | 2 | 0 | |||
| MDS-UPDRS part II | 0.3102 | 0.6287 | 0.0400 | |||
| Mean (SD) | 7.9 (5.7) | 7.0 (5.8) | 8.0 (5.3) | |||
| Missing | 0 | 1 | 2 | |||
| MDS-UPDRS part III, off | 0.0275 | 0.5762 | 0.0002a | |||
| Mean (SD) | 26.2 (10.8) | 22.1 (11.6) | 27.2 (11.1) | |||
| Missing | 19 | 45 | 91 | |||
| MDS-UPDRS part IV, total score | 0.2850 | 0.0027 | 0.0166 | |||
| Mean (SD) | 1.9 (2.8) | 1.4 (2.6) | 0.7 (1.8) | |||
| Missing | 7 | 13 | 66 | |||
| MDS-UPDRS part IV, dyskinesias | 0.7402 | 0.0435 | 0.0320 | |||
| Mean (SD) | 0.4 (0.9) | 0.3 (0.9) | 0.1 (0.5) | |||
| Missing | 7 | 13 | 66 | |||
| MDS-UPDRS part IV, motor fluctuations | 0.4043 | 0.0160 | 0.0509 | |||
| Mean (SD) | 1.2 (1.8) | 0.9 (1.7) | 0.5 (1.3) | |||
| Missing | 7 | 13 | 66 | |||
| Hoehn & Yahr, off | 0.8916 | 0.7463 | 0.5727 | |||
| Stages 0–2, n (%) | 56(91.8) | 104(92.0) | 259 (95.6) | |||
| Stages 3–5, n (%) | 5 (8.2) | 9 (8.0) | 12(4.4) | |||
| Missing | 19 | 45 | 90 | |||
| Modified Schwab & England ADL | 0.1387 | 0.4629 | 0.0025 | |||
| Mean (SD) | 89.3 (10.6) | 91.2 (10.7) | 88.7 (7.8) | |||
| Missing | 0 | 1 | 1 | |||
| TD/Non-TD classification, off | 0.2614 | 0.2282 | 0.0019 | |||
| TD, n (%) | 35 (57.4) | 55 (48.7) | 181 (67.0) | |||
| Missing | 19 | 45 | 91 | |||
| TD/PIGD/indeterminate classification, off | — | — | — | |||
| TD, n (%) | 35 (57.4) | 55 (48.7) | 181 (67.0) | |||
| PIGD, n (%) | 22(36.1) | 49 (43.4) | 61 (22.6) | |||
| Indeterminate, n (%) | 4 (6.6) | 9 (8.0) | 28 (10.4) | |||
| Missing | 19 | 45 | 91 | |||
| MoCA total score | 0.5918 | 0.6534 | 0.1823 | |||
| Mean (SD) | 26.1 (2.9) | 25.9 (3.2) | 26.2 (3.2) | |||
| Missing | 0 | 2 | 3 | |||
| SCOPA-AUT total score | 0.8937 | 0.3430 | 0.1572 | |||
| Mean (SD) | 12.8(7.3) | 12.8 (8.3) | 11.5(6.6) | |||
| Missing | 3 | 7 | 2 | |||
| UPSIT raw score | <0.0001a | 0.0026 | 0.0021 | |||
| Mean (SD) | 19.4(8.2) | 25.0 (7.8) | 22.1 (8.2) | |||
| Missing | 4 | 7 | 0 | |||
| Epworth Sleepiness Scale | 0.2600 | 0.6297 | 0.3240 | |||
| Mean (SD) | 6.5 (4.2) | 7.1 (4.7) | 6.7 (4.2) | |||
| Missing | 3 | 4 | 1 | |||
| RBDSQ | <0.0001a | 0.0799 | 0.0002a | |||
| Mean (SD) | 5.3 (3.7) | 3.5 (2.3) | 4.6 (3.0) | |||
| Missing | 2 | 1 | 0 | |||
| Categorical RBDSQ | 0.0009a | 0.0928 | 0.0112 | |||
| Positive, >4, n (%) | 41 (52.6) | 46 (29.3) | 151 (41.8) | |||
| Missing | 2 | 1 | 0 | |||
| Total LED | 0.8752 | 0.9176 | 0.9289 | |||
| Mean (SD) | 333.0(411.1) | 331.0(330.4) | 315.7(323.0) | |||
Significance defined at P < 0.001.
Report generated on data submitted as of July 1, 2019. P values were found using linear or logistic regression models adjusting for gender and disease duration. MDS-UPDRS part IV (dyskinesias) subscore composed of items 4.1 and 4.2. MDS-UPDRS part IV (motor fluctuations) subscore composed of items 4.3 to 4.5. UPSIT results at BL were used for the sPD cohort (because it was not collected at the year 2 visit). Non-TD includes PIGD and indeterminate groups.
PD, Parkinson’s disease; GBA, glucosylceramidase beta; LRRK2, leucine rich kinase 2; sPD, sporadic PD; BL, baseline; SD, standard deviation; MDS-UPDRS, Movement Disorders Society Unified Parkinson’s Disease Rating Scale; ADL, activities of daily living; TD, tremor dominant; PIGD, postural instability/gait difficulty; MoCA, Montreal Cognitive Assessment; SCOPA-AUT, Scales for Outcomes in PD–Autonomic; UPSIT, University of Pennsylvania Smell Identification Test; LED, levodopa equivalent dose; RBDSQ, Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire.