TABLE 3.
Cognitive performance
| Variable | GBA PD BL Visit, N = 80 | LRRK2 PD BL Visit, N = 158 | sPD Year 2 Visit, N = 361 | P Values | |||
|---|---|---|---|---|---|---|---|
| GBA vs. LRRK2 | GBA vs. sPD | LRRK2 vs. sPD | |||||
| Benton JLO score | 0.7827 | 0.0202 | 0.0007a | ||||
| Mean (SD) | 12.0 (2.7) | 11.8 (2.9) | 12.8 (2.2) | ||||
| Missing | 3 | 6 | 4 | ||||
| HVLT-R immediate recall | 0.9116 | 0.6996 | 0.5087 | ||||
| Mean (SD) | 24.2 (5.1) | 24.3 (5.2) | 23.7 (5.4) | ||||
| Missing | 3 | 4 | 0 | ||||
| HVLT-R delayed recall | 0.9324 | 0.7110 | 0.5463 | ||||
| Mean (SD) | 8.2 (3.0) | 8.2 (3.0) | 8.2 (2.9) | ||||
| Missing | 3 | 4 | 0 | ||||
| HVLT-R retention | 0.7632 | 0.3293 | 0.0894 | ||||
| Mean (SD) | 0.83 (0.25) | 0.82 (0.23) | 0.85 (0.23) | ||||
| Missing | 3 | 4 | 0 | ||||
| HVLT-R discrimination recognition | 0.2919 | 0.0542 | <0.0001a | ||||
| Mean (SD) | 10.2 (1.7) | 9.8 (2.5) | 10.7 (2.4) | ||||
| Missing | 3 | 5 | 0 | ||||
| Letter number sequencing raw score | 0.1070 | 0.9263 | 0.0283 | ||||
| Mean (SD) | 10.4 (2.9) | 9.7 (3.0) | 10.3 (2.8) | ||||
| Missing | 4 | 5 | 0 | ||||
| Semantic fluency total score | 0.2589 | 0.3346 | 0.7165 | ||||
| Mean (SD) | 50.6 (12.1) | 48.9 (12.6) | 48.6 (12.7) | ||||
| Missing | 3 | 5 | 0 | ||||
| Symbol digit modalities score | 0.3227 | 0.1261 | 0.5660 | ||||
| Mean (SD) | 37.8 (11.2) | 39.6 (11.7) | 39.9 (10.9) | ||||
| Missing | 3 | 4 | 0 | ||||
| Cognitive state, clinician rating | 0.7680 | 0.3139 | 0.0905 | ||||
| Normal cognition, n (%) | 67 (87.0) | 136 (88.9) | 297 (83.7) | ||||
| Mild cognitive impairment/dementia, n (%) | 10 (13.0) | 17(11.1) | 58 (16.3) | ||||
| Missing | 3 | 5 | 6 | ||||
| At least 2 scores >1.5 SD below standardized mean | 0.7541 | 0.5893 | 0.8058 | ||||
| No, n (%) | 61 (81.3) | 121 (82.9) | 304 (84.2) | ||||
| Yes, n (%) | 14 (18.7) | 25 (17.1) | 57 (15.8) | ||||
| Missing | 5 | 12 | 0 | ||||
a
Significance defined at P < 0.0017.
Report generated on data submitted as of July 1, 2019. P values were found using linear or logistic regression models adjusting for gender and disease duration. GBA, glucosylceramidase beta; PD, Parkinson’s disease; LRRK2, leucine rich kinase 2; sPD, sporadic PD; BL, baseline; Benton JLO, Benton Judgement of Line Orientation; SD, standard deviation; HVLT-R, Hopkins Verbal Learning Test–Revised.