. Author manuscript; available in PMC: 2021 May 1.

Published in final edited form as: Mov Disord. 2020 Feb 19;35(5):833–844. doi: 10.1002/mds.27989

TABLE 5.

Dopamine transporter 123-I ioflupane single photon emission computed tomography imaging results

Variable	GBA PD BL Visit, N = 80	LRRK2 PD BL Visit, N = 158	sPD Year 2 Visit, N = 361	P Values
Variable	GBA PD BL Visit, N = 80	LRRK2 PD BL Visit, N = 158	sPD Year 2 Visit, N = 361	GBA vs. LRRK2	GBA vs. sPD	LRRK2 vs. sPD
Contralateral caudate SBR				0.4738	0.0021^a	0.0020^a
Mean (SD)	1.74 (0.74)	1.70 (0.52)	1.52 (0.52)
Minimum, maximum	0.49, 3.90	0.60, 3.35	0.06, 3.52
Missing	20	27	28
Ipsilateral caudate SBR				0.3737	0.0288	0.1034
Mean (SD)	1.98 (0.76)	1.92 (0.56)	1.81 (0.58)
Minimum, maximum	0.36, 4.08	0.54, 3.64	0.25, 3.72
Missing	20	27	28
Contralateral putamen SBR				0.2112	<0.0001^a	<0.0001^a
Mean (SD)	0.73 (0.45)	0.69 (0.33)	0.56 (0.22)
Minimum, maximum	0.19, 2.45	0.17, 2.27	0.03, 1.64
Missing	20	27	28
Ipsilateral putamen SBR				0.3533	0.0053	0.0168
Mean (SD)	0.86 (0.48)	0.82 (0.32)	0.74 (0.32)
Minimum, maximum	0.24, 2.79	0.21, 1.90	0.01, 2.12
Missing	20	27	28

Significance defined at P < 0.0042.

Report generated on data submitted as of July 1, 2019. P values were found using linear regression models adjusting for gender and disease duration.

GBA, glucosylceramidase beta; PD, Parkinson’s disease; LRRK2, leucine rich kinase 2; sPD, sporadic PD; BL, baseline; SBR, specific binding ratio; SD, standard deviation.