Table 3.
Association Between Methylation Rate of RNF180 and Clinicopathological Parameters in GC
| Variability | n | AMR | M3 | M5 | M7 | M8 | M27 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median (25th,75th) | *P value | Median (25th,75th) | *P value | Media(25th,75th) | *P value | Media(25th,75th) | *P value | Media(25th,75th) | *P value | Media(25th,75th) | *P value | ||
| Gender | 0.732 | 0.783 | 0.801 | 0.590 | 0.654 | 0.753 | |||||||
| Male | 112 | 0.28(0.18,0.38) | 0.43(0.13,0.55) | 0.31(0.14,0.52) | 0.44(0.15,0.56) | 0.41(0.13,0.52) | 0.38(0.14,0.60) | ||||||
| Female | 52 | 0.27(0.11,0.35) | 0.40(0.11,0.56) | 0.26(0.12,0.53) | 0.40(0.09,0.58) | 0.39(0.12,0.50) | 0.38(0.18,0.58) | ||||||
| Age | 0.731 | 0.338 | 0.999 | 0.805 | 0.694 | 0.289 | |||||||
| >60 | 96 | 0.29(0.14,0.39) | 0.45(0.13,0.56) | 0.29(0.13,0.52) | 0.43(0.14,0.56) | 0.40(0.12,0.52) | 0.40(0.16,0.61) | ||||||
| ≤60 | 68 | 0.28(0.18,0.36) | 0.40(0.15,0.53) | 0.32(0.12,0.51) | 0.45(0.14,0.56) | 0.40(0.14,0.50) | 0.33(0.16,0.54) | ||||||
| Smoking | 0.563 | 0.443 | 0.375 | 0.564 | 0.760 | 0.711 | |||||||
| Yes | 56 | 0.30(0.18,0.41) | 0.37(0.13,0.55) | 0.35(0.12,0.52) | 0.40(0.14,0.55) | 0.42(0.12,0.52) | 0.41(0.19,0.60) | ||||||
| No | 108 | 0.27(0.15,0.36) | 0.45(0.14,0.56) | 0.26(0.13,0.50) | 0.44(0.12,0.58) | 0.40(0.13,0.51) | 0.37(0.15,0.58) | ||||||
| Lymph node metastasis | 0.305 | 0.12 | 0.575 | 0.536 | 0.859 | 0.102 | |||||||
| Positive | 101 | 0.30(0.13,0.39) | 0.37(0.13,0.54) | 0.34(0.13,0.53) | 0.42(0.12,0.56) | 0.39(0.12,0.52) | 0.41(0.18,0.61) | ||||||
| Negative | 63 | 0.26(0.18,0.36) | 0.49(0.17,0.56) | 0.28(0.12,0.50) | 0.48(0.16,0.56) | 0.43(0.17,0.51) | 0.34(0.14,0.56) | ||||||
| Histologic differentiation | 0.317 | 0.872 | 0.548 | 0.314 | 0.972 | 0.253 | |||||||
| Well | 69 | 0.27(0.12,0.35) | 0.44(0.10,0.57) | 0.30(0.11,0.52) | 0.38(0.13,0.55) | 0.39(0.10,0.51) | 0.34(0.15,0.57) | ||||||
| Poorly | 95 | 0.28(0.18,0.39) | 0.43(0.14,0.54) | 0.33(0.18,0.52) | 0.44(0.14,0.57) | 0.41(0.14,0.51) | 0.41(0.17,0.60) | ||||||
| Vascular cancer embolus | 0.037 | 0.214 | 0.118 | 0.132 | 0.286 | 0.039 | |||||||
| Positive | 44 | 0.32(0.23,0.46) | 0.46(0.28,0.56) | 0.36(0.20,0.54) | 0.49(0.32,0.58) | 0.43(0.22,0.53) | 0.45(0.25,0.67) | ||||||
| Negative | 120 | 0.27(0.12,0.35) | 0.41(0.11,0.55) | 0.28(0.12,0.50) | 0.42(0.11,0.55) | 0.39(0.11,0.51) | 0.35(0.15,0.55) | ||||||
| Lauren’s classification | 0.772 | 0.593 | 0.391 | 0.357 | 0.955 | 0.723 | |||||||
| Intestinal-type | 96 | 0.28(0.18,0.38) | 0.42(0.14,0.54) | 0.29(0.16,0.48) | 0.44(0.13,0.58) | 0.40(0.13,0.52) | 0.39(0.15,0.60) | ||||||
| Diffuse-type | 68 | 0.28(0.14,0.37) | 0.45(0.12,0.57) | 0.32(0.11,0.58) | 0.40(0.14,0.55) | 0.40(0.12,0.51) | 0.36(0.18,0.56) | ||||||
| Growth pattern | 0.422 | 0.942 | 0.822 | 0.797 | 0.909 | 0.542 | |||||||
| Expanding | 57 | 0.24(0.13,0.36) | 0.43(0.11,0.56) | 0.30(0.12,0.51) | 0.40(0.11,0.56) | 0.39(0.12,0.51) | 0.34(0.15,0.58) | ||||||
| Infiltrative | 107 | 0.30(0.18,0.39) | 0.44(0.14,0.55) | 0.33(0.14,0.52) | 0.44(0.14,0.56) | 0.41(0.13,0.52) | 0.41(0.16,0.60) | ||||||
| Invasion depth | 0.232 | 0.136 | 0.272 | 0.383 | 0.953 | 0.195 | |||||||
| T1/T2 | 84 | 0.28(0.13,0.34) | 0.41(0.10,0.53) | 0.28(0.12,0.50) | 0.43(0.10,0.56) | 0.42(0.12,0.50) | 0.34(0.15,0.57) | ||||||
| T3/T4 | 80 | 0.29(0.18,0.42) | 0.45(0.15,0.56) | 0.33(0.16,0.56) | 0.45(0.24,0.56) | 0.39(0.13,0.52) | 0.42(0.16,0.60) | ||||||
| Metastasis | 0.864 | 0.062 | 0.428 | 0.068 | 0.449 | 0.831 | |||||||
| Positive | 66 | 0.29(0.12,0.37) | 0.31(0.10,0.54) | 0.34(0.13,0.54) | 0.37(0.11,0.54) | 0.37(0.12,0.50) | 0.40(0.18,0.58) | ||||||
| Negative | 98 | 0.28(0.19,0.38) | 0.46(0.19,0.56) | 0.29(0.15,0.48) | 0.48(0.18,0.57) | 0.42(0.14,0.51) | 0.37(0.15,0.60) | ||||||
| TNM Stages | 0.067 | 0.285 | 0.816 | 0.703 | 0.697 | 0.054 | |||||||
| I | 23 | 0.23(0.19,0.29) | 0.49(0.28,0.56) | 0.28(0.19,0.46) | 0.48(0.23,0.56) | 0.45(0.19,0.51) | 0.22(0.14,0.43) | ||||||
| II | 33 | 0.27(0.17,0.33) | 0.51(0.14,0.57) | 0.23(0.11,0.49) | 0.42(0.29,0.57) | 0.46(0.16,0.53) | 0.34(0.17,0.52) | ||||||
| III | 106 | 0.30(0.12,0.40) | 0.38(0.11,0.53) | 0.34(0.13,0.54) | 0.43(0.11,0.55) | 0.37(0.11,0.51) | 0.42(0.17,0.63) | ||||||
| IV | 2 | \ | \ | \ | \ | \ | \ | ||||||
| Total | 164 | 0.28(0.17,0.37) | \ | 0.43(0.13,0.56) | \ | 0.31(0.13,0.52) | \ | 0.44(0.14,0.56) | \ | 0.40(0.13,0.51) | \ | 0.38(0.16,0.59) | \ |
Note: *P value: Mann–Whitney U-test.
Abbreviations: AMR, average methylation rate; GC, gastric cancer.