Table 4.
Survival Analysis Combined with Clinical Parameter and Methylation
| Variability | n | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| HR(95% CI) | P value | HR(95% CI) | P value | ||
| Gender | |||||
| Male | 112 | 1(Ref.) | |||
| Female | 52 | 1.128(0.659,1.930) | 0.661 | ||
| Age | |||||
| >60 | 96 | 1(Ref.) | |||
| ≤60 | 68 | 1.291(0.781,2.134) | 0.320 | ||
| Smoking | |||||
| No | 108 | 1(Ref.) | |||
| Yes | 56 | 1.561(0.947,2.575) | 0.081 | ||
| Lymph node metastasis | |||||
| Negative | 63 | 1(Ref.) | 1(Ref.) | ||
| Positive | 101 | 5.913(2.815,12.418) | 0.00000268 | 3.188(1.271,7.996) | 0.013 |
| Histological differentiation | |||||
| Well | 69 | 1(Ref.) | |||
| Poorly | 95 | 0.652(0.387,1.099) | 0.109 | ||
| vascular cancer embolus | |||||
| Positive | 44 | 1(Ref.) | 1(Ref.) | ||
| Negative | 120 | 1.711(1.025,2.857) | 0.040 | 1.498(0.855,2.624) | 0.158 |
| Lauren’s classification | |||||
| intestinal-type | 96 | 1(Ref.) | |||
| Diffuse-type | 68 | 0.824(0.495,1.374) | 0.459 | ||
| Growth pattern | |||||
| Expanding | 57 | 1(Ref.) | 1(Ref.) | ||
| Infiltrative | 107 | 0.555(0.315,0.997) | 0.041 | 2.120(4.386,1.025) | 0.043 |
| Invasion depth | |||||
| T1/T2 | 84 | 1(Ref.) | |||
| T3/T4 | 80 | 0.899(0.551,1.468) | 0.670 | ||
| Metastasis | |||||
| Negative | 98 | 1(Ref.) | 1(Ref.) | ||
| Positive | 66 | 2.096(1.280,3.434) | 0.003 | 1.018(0.504,2.055) | 0.960 |
| TNM Stages | |||||
| I/II | 56 | 1(Ref.) | 1(Ref.) | ||
| III/IV | 108 | 5.657(2.576,12.420) | 0.00001571 | 3.269(1.389,7.696) | 0.007 |
| AMR | |||||
| ≤0.3 | 93 | 1(Ref.) | 1(Ref.) | ||
| >0.3 | 71 | 1.832(1.118,3.000) | 0.016 | 1.940(1.165,3.230) | 0.011 |
| M5 | |||||
| ≤0.3 | 81 | 1(Ref.) | 1(Ref.)a | ||
| >0.3 | 83 | 2.423(1.371,4.280) | 0.002 | 1.874.(1.099,3.182) | 0.021 |
| M27 | |||||
| ≤0.3 | 66 | 1(Ref.) | 1(Ref.)a | ||
| >0.3 | 98 | 1.885(1.136,3.130) | 0.013 | 2.441(1.362,4.371) | 0.003 |
Note: aConsider the clinical parameters which effect prognosis, we include smoke, Lymph node metastasis, histological differentiation, growth pattern, vascular cancer embolus, invasion depth, TNM stage, metastasis into the multi-factor COX regression.
Abbreviations: HR, hazard ratio; CI, confidence interval.