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. 2020 May 12;13:4049–4061. doi: 10.2147/OTT.S251518

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© 2020 Wang et al.

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MALAT1 up-regulation enhanced DDP resistance and MALAT1 down-regulation reversed DDP resistance on cell proliferation and colony formation in human OSCC cell lines. (A, B) CCK-8 assay: indicated cells were treated with different concentrations of DDP as indicated. Cell viability was determined in 48h. (B) qPCR: MALAT1 overexpression validation in CAL-27. (C–J) colony formation assay was utilized to evaluate the capability of indicated cells with indicated treatment on colony formation. ***P<0.001, compared with Vector group. ^##P<0.01, ^###P<0.001, compared with MALAT1+DDP or si-MALAT1+DDP group.