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. 2020 May 12;13:4035–4048. doi: 10.2147/OTT.S254133

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© 2020 Chen et al.

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circRUNX1 was upregulated in CRC tissues and correlated with tumor progression. (A) qRT-PCR for circRUNX1 in 52 pairs of CRC and matched adjacent normal mucosal tissues showed that circRUNX1 was significantly upregulated. (B) 69.2% (36 of 52) of the CRC tissues presented increased expression of circRUNX1 compared to matched normal tissues. (C) Using the median expression level of circRUNX1 as a cutoff value, the 52 CRC tissues were divided into low and high expression groups. (D) The level of circRUNX1 showed an increased trend with TNM tumor stage. All data are presented as the means ± SD of at least three independent experiments. ***p< 0.001. T, tumor tissues; N, normal tissues.