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. 2020 May 13;13:4113–4122. doi: 10.2147/OTT.S245848

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© 2020 Zhu et al.

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Effect of BTK overexpressing on the cell migration and invasion. Plasmid containing negative control (NC) or overexpressing BTK (OE) sequence were transfected into DU145 cell or PC3 cell as described in the methods. Cells were then treated with 5µM Ibrutinib followed by migration and invasion assay as described in the methods. (A and B) Migration (A) and invasion (B) of DU145 cells. Insert quantification of the migrated and invaded cell number. Vertical axes: migrated or invaded cell number per field; horizontal axes: cells transfected with negative control or overexpressing BTK and treated with or without 5µM Ibrutinib. (C and D) Migration (C) and invasion (D) of PC3 cells. Insert quantification of the migrated and invaded cell number. Vertical axes: migrated or invaded cell number per field; horizontal axes: cells transfected with negative control or overexpressing BTK and treated with or without 5µM Ibrutinib. **P < 0.01; ***P < 0.001.