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. 2020 May 11;12:3285–3291. doi: 10.2147/CMAR.S249237

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© 2020 Xue et al.

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CircPRMT5 promotes E2F3 expression via targeting miR-30c. (A and B) Luciferase reporter assay showed that miR-30c mimic inhibited the activity of circPRMT5-WT reporter vector. (C and D) RIP assay showed that circPRMT5 interacted with miR-30c. (E) miR-30c expression was upregulated after circPRMT5 knockdown. (F) The binding site of miR-30c in E2F3 was predicted by TargetScan7. (G and H) Luciferase reporter assay showed that miR-30c mimic inhibited the activity of E2F3-WT reporter vector. (I) miR-30c mimics suppressed E2F3 expression. (J) qRT-PCR analysis showed that E2F3 expression was regulated by circPRMT5/miR-30c axis. *p<0.05.