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. 2020 May 12;13:4089–4097. doi: 10.2147/OTT.S241640

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© 2020 Wang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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CDK1 was a direct binding target of miR-153-5p. (A) The 3ʹ‐UTR of CDK1 harbors miR-153-5p cognate sites. (B) Relative luciferase activity of reporter plasmids carrying WT- or MT-CDK1 3ʹ‐UTR in MDA-MB-231/PTX cells following co‐transfecting with miR-153-5p was detected using dual-luciferase reporter assay. (C) MDA-MB-231/PTX cells were transfected with miR-153-5p for 72 h. RT-qPCR was applied to measure the level of CDK1 in cells. **P<0.01 compared with vector-control group.

Abbreviations: WT, wild-type; MT, mutant; NC, negative control.