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. 2020 May 15;13(7):100769. doi: 10.1016/j.tranon.2020.100769

Figure 5.

Figure 5

The effect of combinatorial treatment with CDDP and MK2206 on the growth of a P19 subcutaneous xenograft tumor in vivo. (A) The change of subcutaneous P19 tumor volume measured using the Vernier caliper. After tumors reached the indicated volume, tumor-bearing mice were treated with indicated drugs as shown in the figure and described in section “Materials and methods”, and the effect of the indicated drugs on tumor growth was measured using the Vernier caliper. (B) Histological examination of the effect of CDDP and MK2206 on a P19 tumor in vivo. At day 15, the mice were sacrificed and the tumors were dissected. The expression of Ki-67 was assessed by immunohistochemistry. The percentage of Ki-67-positive cells in each treatment group was compared (*P < 0.05 vs. control; **P < 0.05, CDDP+MK2206 vs. CDDP; CDDP+ MK2206 vs. MK2206).