Figure 1.

Schematic of influenza A virions bound to Texas Red lipid-labeled target vesicles. Vesicles (red) are bound to virions by (A) hybridization of complementary sequences of membrane-anchored DNA (purple) or (B) both membrane-anchored DNA and GD1a glycolipid receptors (black). GD1a binds to viral HA (blue). In both architectures, the substrate displays single-stranded DNA (green). Virions are surface tethered by DNA hybridization with a membrane-anchored antisense DNA sequence (green) that is orthogonal to the sequence used for viral tethering (purple). Details of surface functionalization are not shown (see Supporting Materials and Methods); the schematic is not drawn to scale. To see this figure in color, go online.