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. 2020 Apr 15;118(10):2612–2620. doi: 10.1016/j.bpj.2020.03.032

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© 2020 Biophysical Society.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Noise analysis of hKv2.1-T377A and hKv3.1-T400A to determine channel conductance. (a) shows the representative current recordings of hKv2.1-T377A (left) and hKv3.1-T400A (right) elicited by repetitively applying a +40-mV pulse. The gray trace is the calculated average. (b) and (c) plot the calculated variance, obtained from analyzing the upstroke of the activating current recordings shown in (a), as a function of current amplitude. Fitting these relationships with a parabolic function (gray tracing) yielded a single-channel current i of 0.48 pA for hKv2.1-T377A (b) and 0.65 pA for hKv3.1-T400A (c), respectively. These single-channel currents correspond to a single-channel conductance γ, represented in parentheses.