Table 1.
GV Curve, Ion Selectivity, and Unitary Conductance Properties of WT and Mutant Channels, with n the Number of Cells Analyzed
GV Curve |
Selectivity |
n | γ (pS) | n | ||
---|---|---|---|---|---|---|
V1/2 (mV) | Slope k | Ratio Na+/K+ | ||||
WT Kv2.1 | 12.2 ± 1.4 | 9.5 ± 0.6 | 0.015 ± 0.004 | 7 | 10.3 ± 0.4 | 3 |
T377A | −45.8 ± 2.4 | 9.9 ± 0.6 | 0.010 ± 0.002 | 6 | 4.9 ± 0.3 | 3 |
WT Kv3.1 | 23.5 ± 1.0 | 5.6 ± 0.3 | 0.014 ± 0.003 | 6 | 24.1 ± 3.1 | 3 |
T400A | −62.2 ± 2.9 | 11.9 ± 1.1 | 0.013 ± 0.002 | 5 | 5.6 ± 0.6 | 3 |