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. 2019 Aug 7;22:132–141. doi: 10.1016/j.jot.2019.07.003

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

AP inhibited DOX-induced enhancement of migration of osteosarcoma. (A and B) Transwell assay was carried out to examine the effects of AP, DOX, or AP+DOX on migratory capacity of KHOS and U2OS cells. (C–F) Migration-related proteins (E-cadherin, N-cadherin, vimentin, and MMP-9) of AP-, DOX-, or AP+DOX–treated KHOS and U2OS cells were measured by western blot assay. Data are represented as the mean ± SD. ***P < 0.001. AP = apatinib; DOX = doxorubicin; MTT = 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; MMP = matrix metalloproteinase; SD = standard deviation.