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. 2019 Aug 7;22:132–141. doi: 10.1016/j.jot.2019.07.003

Figure 5.

Figure 5

Sox2 overexpression abolishedthe inhibitory effects of AP on DOX-induced osteosarcoma cell migration. (A and B) Cell migration of DOX- or AP+DOX–treated KHOS and U2OS cells was measured by transwell assay after transfecting with Sox2. (C and D) Protein expression of E-cadherin, N-cadherin, vimentin, and MMP-9 was detected by western blot assay in Sox2-overexpressed KHOS cells treated with DOX or AP+DOX. (E and F) Protein expression of E-cadherin, N-cadherin, vimentin, and MMP-9 was detected by western blot assay in Sox2-overexpressed U2OS cells treated with DOX or AP+DOX. Data are represented as the mean ± SD. ***P < 0.001. AP = apatinib; DOX = doxorubicin; MMP = matrix metalloproteinase; SD = standard deviation.