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. 2019 Nov 15;22:124–131. doi: 10.1016/j.jot.2019.10.009

Figure 7.

Figure 7

(A) Lubricin overexpression are presented in endplate chondrocytes. (B–C) As the chondrocytes were co-cultured with P. acnes supernatant fluid (at concentrations of 1%), lubricin overexpression could downregulate the gene expression of MMP-1(B), ADAMTS5(C). (D) Western blot analysis showed lubricin overexpression could downregulate protein level of MMP-1 and ADAMTS5. (E–F) lubricin overexpression could downregulate the expression of IL-1β(E) and IL-6(F) compared with negative control (*p< 0.05, ** p< 0.01,*** p< 0.005).