Table 1.

Redox-sensitive proteins in autophagy.

Protein	Function in autophagy machinery	Redox-Sensitive Cys residues	Outcome of Oxidation	Autophagy Outcome
MCOLN1	Indirect	not identified	Ca2+ release, TFEB activation [23]	↑	ATG and lysosomal gene transcription
KEAP1	Indirect	multiple	NRF2 release [53]	↑	ATG, NRF2, p62 transcription
p62	Selective cargo recognition	Cys105 and Cys113	Oligomerisation [47]	↑	Autophagy stimulation
ATG3	Autophagosome elongation	Cys264	Loss of LC3-PE formation [37]	↓	Autophagosome formation
ATG4B	Pro-LC3 processing, LC3-PE deconjugation	Cys74 or Cys78	Loss of deconjugating activity [16]	↑	Autophagosome formation
ATG7	Autophagosome elongation	Cys572	Loss of LC3-PE formation [37]	↓	Autophagosome formation
ATM	Indirect	Cys2991	ATM recruitment to peroxisome [80]	↑	Pexophagy