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. 2020 May 4;23(5):101125. doi: 10.1016/j.isci.2020.101125

Figure 3.

Figure 3

SLC37A2 Deletion Broadly Rewires Macrophage Metabolism at Both Transcriptional and Metabolic Levels

(A) Heatmap of genes in the pathway of carbohydrate derivative transporters from resting WT and Slc37a2−/− BMDMs, assessed by RNA-seq (three biologically independent samples per group).

(B) The enriched metabolic KEGG pathways in resting Slc37a2−/− versus WT BMDMs are shown and ranked according to p values, assessed by RNA-seq.

(C) Heatmap of genes under the category of metabolism in resting WT and versus Slc37a2−/− BMDMs, determined by RNA-seq.

(D) Score plots of principal component analysis of the untargeted metabolomics data collected using WT and Slc37a2−/− BMDMs treated with 100 ng/mL LPS for 0 or 3 h (n = 6 per group).

(E) Heatmap displaying hierarchical clustering analysis of metabolites in WT and Slc37a2−/− BMDMs treated with 100 ng/mL LPS for 0 or 3 h.

(F) Results of random forest analysis showing mean decrease accuracies of the top 15 metabolites altered in WT and Slc37a2−/− BMDMs treated with 100 ng/mL LPS for 0 or 3 h.

KO, Slc37a2−/−.

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