Figure 4.

SLC37A2 Deletion Accelerates Basal Glycolysis and Mitochondrial Oxidative Phosphorylation

(A) Diagram of glycolysis, pentose phosphate pathway (PPP), and TCA cycle.

(B–D) Basal levels of metabolites in resting WT and Slc37a2^−/− BMDMs in the pathways of glycolysis, PPP, and TCA, respectively.

(E) Seahorse analysis of basal extracellular acidification rates (ECAR) and ECAR after glucose injection in resting WT and Slc37a2^−/− BMDMs.

(F) Seahorse analysis of basal and maximal oxygen consumption rate (OCR) in resting WT and Slc37a2^−/− BMDMs.

Data are represented as mean ± SEM (n = 6 per group). ∗p < 0.05, ∗∗∗p < 0.001, ∗∗∗∗p < 0.001, unpaired, two-tailed Student's t test.