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. 2020 May 4;23(5):101125. doi: 10.1016/j.isci.2020.101125

Figure 7.

Figure 7

SLC37A2 Overexpression Represses Macrophage Pro-inflammatory Activation

(A and B) Slc37a2 and cytokine expression in human SLC37A2 overexpressing Raw 264.7 macrophages stably transfected with empty vector (EV) or human SLC37A2 plasmid (Slc-OE). Cells were treated with or without 100 ng/mL LPS for 4 h.

(C and D) Seahorse analysis of ECAR and OCR after sequential injection of glucose (25 mM), oligomycin (1 μM), and 2-deoxyglucose (2-DG, 20 mM), in control and SLC37A2-overexpressing cells treated with or without 100 ng/mL LPS for 3 h.

Data are representative of two independent experiments with four samples per group (mean ± SEM). ∗ p < 0.05, ∗∗p < 0.01, ∗∗∗ p < 0.001, two-way ANOVA with post hoc Tukey's multiple comparisons test (A and B) and unpaired, two-tailed Student's t test (C and D).