Table 1.
Patient characteristics
|
RAS WT BRAF V600E WT (n = 291) |
RAS WT BRAF or PIK3CA MT (n = 52) |
P⁎⁎ | ||
|---|---|---|---|---|
| Median (range) age, years Mean ± SD |
66 (30–90) 64 ± 11 |
65 (40–88) 63 ± 13 |
.66 | |
| Sex | Male Female |
64% 36% |
38% 62% |
<.001 |
| Primary tumor site |
Right-colon Left-colon Rectum |
11% 34% 55% |
57% 12% 31% |
<.001 |
| Stage | Localized Metastatic |
19% 81% |
12% 88% |
.24 |
| Histology* | Tub Por/Muc/Sig |
91% 9% |
80% 20% |
.043 |
| Metastatic tumor site |
Liver Lung Lymph node Peritoneum |
66% 32% 25% 15% |
37% 17% 39% 35% |
<.001 .051 .069 .003 |
Abbreviations: WT, wild-type; MT, mutant; SD, standard deviation; Tub, tubular adenocarcinoma; Por, poorly differentiated adenocarcinoma; Muc, mucinous adenocarcinoma; Sig, signet ring cell carcinoma. * Japanese Classification of Colorectal Carcinoma-Second English Edition. **Fisher's exact test.