Table 3.

Clinical trials with the largest effect sizes

Trial	Meta ID	Diagnosis |ES|	Treatments A > B	Quality	PQRS total	Citations #	Direct attempts	Conceptual attempts
Ayen and Hautzinger (2004)	4, 5	Depression 1.56	CBT > SUP	*	*	9	0	0
de Jong et al. (1986)	3	Depression, Dysthymia 1.03	CBT > SUP	Moderately poor	24	1	0	0
Durham et al. (1994)	1, 6, 9, 10	GAD 0.9	CT > DYN	Average	31	101	0	3
Gallagher-Thompson and Steffen (1994)	9, 5	Depression 1.27	CBT > DYN	Moderately good	37	126	0	3
Klausner et al. (1998)	2	Depression 1.4	GFT > REM	Very poor	18	57	0	1
Latour and Cappeliez (1994)	2	Depression 0.92	CBT > CT	Moderately poor	22	16	0	1
Milrod et al. (2007)	6	Anxiety 0.89	DYN > AR	Very good	43	147	0	0
Norton (2012)	8	Anxiety, Depression 1.54	TRN > RLX	Moderately good	37	72	0	0
Shapiro et al. (1994)	9	Depression 1.44	CBT > DYN	Very good	41	268	0	2
Shaw (1977)	4, 5	Depression		Very poor	18	200	0	5
		1.13	CT > BAT
		0.94	BAT > SUP
Shear et al. (2001)a	1, 9, 10	PD 0.8	CBT > EFT	Moderately poor	26	38	0	0
Taylor and Marshall (1977)	5	Depression 0.89	CBT > BAT	Exceptionally poor	16	0	0	0

CBT, cognitive behaviour therapy; CT, cognitive therapy; DYN, dynamic therapy; REM, reminiscence psychotherapy; EFT, emotion-focused therapy; TRN, transdiagnostic therapy; SUP, supportive therapy; BAT, behavioural activation therapy; RLX, relaxation therapy; GFT, goal-focused therapy; CT, cognitive therapy; AR, applied relaxation, quality ratings were averaged between two independent raters; GAD, generalised anxiety disorder; PD, panic disorder.

^aManual not available.

*Trial unavailable in English. Quality = item 25 from the PQRS.