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Amino acid sequences of ASIC1a and/or ASIC3 inhibitors from spider, snake, and sea anemone. Active sites are indicated by asterisks above the residues: PcTx1, mambalgin-1, and APETx2 residues that, when mutated to alanine, have a major impact on the peptides inhibitory activity toward ASICs [13,31,45,46], and Hcr 1b-2 and Hcr 1b-4 residues forming hot spot interactions. Homologous sea anemone peptides are grouped and identical amino acid residues are shown on a dark gray background.
