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Anti-CRISPR proteins as an intracellular public good. A first (altruistic) virus expresses Acr proteins, but these are not sufficient to inactivate the CRISPR system, leading to degradation of the viral genome and abortive infection. However, the cell remains in a transient immunosuppressed state due to the action of the Acr proteins, which allows a second (potentially identical) virus to overcome CRISPR and successfully complete the infection.
