Table 4.
Combinatory effect of lithocholic acid (LCA) with several drugs against H. pylori.
| Strain | Combination Tested | FICdrug | FICLCA | FICI a | Interaction b |
|---|---|---|---|---|---|
| ATCC 700684 | LCA + Clarithromycin | 0.031 | 0.5 | 0.53 | Additive |
| ATCC 43504 | LCA + Metronidazole | 1 | 1 | 2 | No interaction |
| ATCC 700392 | LCA + Levofloxacin | 0.5 | 0.5 | 1 | Additive |
| ATCC 700392 | LCA + Chrysin | 0.25 | 0.5 | 0.75 | Additive |
aFractional inhibitory concentration index (FICI) could be calculated as: FICA (MICA in the presence of B/MICA alone) + FICB (MICB in the presence of A/MICB alone). bAccording to the FICI value, the interaction between two compounds against a particular bacterial strain can be classified as: synergy (FICI ≤ 0.5), additive (FICI >0.5 to ≤1), no interaction or neutral (FICI > 1 to ≤ 4), and antagonism (FICI > 4).