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. 2020 Apr 15;8(4):574. doi: 10.3390/microorganisms8040574

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Overview of the principal metabolic pathways for organic acid synthesis in Y. lipolytica. ACL: ATP citrate lyase; ACC: acetyl CoA carboxylase; ACO: aconitase; ACO *: truncated aconitase (for cytosol localization); ACH: acetyl CoA hydrolase; CAD: cis-aconitate decarboxylase; CIT: citrate synthase; DHAP: dihydroxyacetone-P; FUM: fumarase; GK: glycerol kinase; G3PDH: glycerol-3P dehydrogenase; ICL: isocitrate lyase; IDH: isocitrate dehydrogenase; MLS: malate synthase; PEP: phosphoenol pyruvate; PYC: pyruvate carboxylase; SCS: succinyl CoA synthetase; SDH: succinate dehydrogenase; PCK: phosphoenolpyruvate carboxykinase; αKD: αketoglutarate dehydrogenase.