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Graphical abstract: HCV proteins are susceptible to degradation after oxidative stress induction. In Huh7 cells expressing HCV viral proteins and under oxidative stress conditions, we observed that HCV Core or/and NS5A proteins were susceptible to degradation after induction of external oxidative stress. The phosphorylation of eIF2α was followed by increased expression of ATF4 and CHOP. Autophagy-related proteins (LC3-II/p62) are involved in the degradation of HCV proteins.
