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. 2020 Mar 31;12(4):219. doi: 10.3390/toxins12040219

Figure 5.

Figure 5

The effect of CYN (0.5 µg/mL), BPs (BPA, BPS, BPF, BPAF; 10 µg/mL), and their binary mixtures on the expression of oxidative stress response genes (GCLC, GPX1, GSR, SOD1A, CAT) in HepG2 cells after 24 h of exposure. The deregulations are expressed in fold-change of expression of the gene in the solvent control group (0.05% methanol and 0.04% DMSO = solid line at value 1.0). PC is the positive control—Benzo[a]pyrene BaP (30 μM). The lower and upper dotted lines denote biologically significant differences in gene expression (1.5-fold change). The asterisks (*) denote a statistically significant difference between solvent control and treated cells (* p = 0.05; ** p = 0.01; *** p = 0.001).