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. 2020 Apr 9;12(4):239. doi: 10.3390/toxins12040239

Figure 4.

Figure 4

Carlina oxide is toxic to zebrafish embryos. (A) Mortality of zebrafish treated with carlina oxide (3.125–25 μg/mL) at the 96 h of the ZFET test. (B) Effects of carlina oxide on the heart rate of larval zebrafish at the 96 hpf of the ZFET test. Data represent mean ± SD, n = 10, *, p < 0.05 vs. negative control (E3), Dunnett’s test. (C) Teratogenic effects of carlina oxide on zebrafish larvae at the 96 h of the ZFET test (top panel: negative control – E3 medium; bottom panel: carlina oxide, 25 μg/mL). CFM, craniofacial malformation; YSO, yolk sac oedema; ST: shortened tail.