Figure 4.
YrbE3A expression promoted lung inflammatory lesions in mice infected with recombinant Ms_YrbE3A and Ms_Vec. (A) Mice were infected with Ms_YrbE3A and Ms_Vec at a dose of 2.0 × 106 CFU via intratracheal challenge for different times, euthanized at day 2, 4, and 6 postinfection, and lung tissues were observed after being sectioned and stained with Hematoxylin and eosin (H&E) stain. Scale bar: 50 µm. Data are representative of one experiment with two independent biological replicates (mean ± SEM of n = 5 mice per group in (A). (B) Densitometry quantification of cell numbers per field for neutrophils, lymphocytes, and monocytes *p < 0.05 and **p < 0.01 (two-tailed unpaired t-test).