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The role of the distinct two catalytic sites of angiotensin‐converting enzyme (ACE) in tissue fibrosis. The C‐terminal catalytic site of ACE shows a higher affinity to angiotensin I. In contrast, the N‐terminal catalytic site of ACE shows a high affinity to N‐acetyl‐seryl‐aspartyl‐lysyl‐proline (AcSDKP), and AcSDKP could be only degraded by the N‐terminal catalytic site.
