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. 2020 Apr 16;12(4):258. doi: 10.3390/toxins12040258

Table 1.

Final list of ligands and related proteins.

Ligand PDB ID Protein PDB ID Protein Name Source Organism Note
TI2/TIO 1QF0/1ZDP Thermolysin * Bacteria a
CXA 4DJL Carboxypeptidase T (CPT) Bacteria a
CXA/ING 1IY7 Carboxypeptidase A (CPA) * Bovine a
CXA 5J1Q Carboxypeptidase B (CPB) Pig a
FC0 1BCR/1WHT Serine Carboxypeptidase II (Ser-CP II) Wheat a
TIO 5V48 Neprilysin Rabbit a
9UP 4FUG Urokinase Human a
46L 4Y3S Endothiapepsin Fungus a
S61 4AZ0 Cathepsin A Human a
DSV 2K2G Matrix metalloproteinase 12 (MMP-12) Human a
1CH/ZY4/192 2WF4/1W51/4I11 Beta-secretase 1 (BACE 1) Human a
BBL 1ESB Pancreatic elastase Pig a
P28 2ROY Transthyretin Human b
9NF 2WX0 Serum albumin ** Human b
1HN 3NKT Salicylate 1,2-dioxygenase Bacteria c
NPQ 5FJO N-acyl amino acid racemase Bacteria c

Note: a indicates potential OTA hydrolyzing enzymes (Figure 1); b indicates potential OTA binding proteins; c indicates potentially non-OTA hydrolyzing enzymes, able to transform OTA using other mechanisms than the hydrolysis of amidic bond. * Thermolysin and Carboxypeptidase A known for OTA hydrolyzing activity [20,21,28]. ** Serum albumin known as OTA binder [29,30,31].