Table 1.
Ligand PDB ID | Protein PDB ID | Protein Name | Source Organism | Note |
---|---|---|---|---|
TI2/TIO | 1QF0/1ZDP | Thermolysin * | Bacteria | a |
CXA | 4DJL | Carboxypeptidase T (CPT) | Bacteria | a |
CXA/ING | 1IY7 | Carboxypeptidase A (CPA) * | Bovine | a |
CXA | 5J1Q | Carboxypeptidase B (CPB) | Pig | a |
FC0 | 1BCR/1WHT | Serine Carboxypeptidase II (Ser-CP II) | Wheat | a |
TIO | 5V48 | Neprilysin | Rabbit | a |
9UP | 4FUG | Urokinase | Human | a |
46L | 4Y3S | Endothiapepsin | Fungus | a |
S61 | 4AZ0 | Cathepsin A | Human | a |
DSV | 2K2G | Matrix metalloproteinase 12 (MMP-12) | Human | a |
1CH/ZY4/192 | 2WF4/1W51/4I11 | Beta-secretase 1 (BACE 1) | Human | a |
BBL | 1ESB | Pancreatic elastase | Pig | a |
P28 | 2ROY | Transthyretin | Human | b |
9NF | 2WX0 | Serum albumin ** | Human | b |
1HN | 3NKT | Salicylate 1,2-dioxygenase | Bacteria | c |
NPQ | 5FJO | N-acyl amino acid racemase | Bacteria | c |
Note: a indicates potential OTA hydrolyzing enzymes (Figure 1); b indicates potential OTA binding proteins; c indicates potentially non-OTA hydrolyzing enzymes, able to transform OTA using other mechanisms than the hydrolysis of amidic bond. * Thermolysin and Carboxypeptidase A known for OTA hydrolyzing activity [20,21,28]. ** Serum albumin known as OTA binder [29,30,31].