Table 5.
Transcription factor motifs site/sequence matrix identified in the proximal promoter region of genes upregulated by Meth alone, from the comparison between Tat−/Meth versus Tat−/Sal brains, and of genes upregulated by Tat in the context of Meth, from the comparison between Tat+/Meth versus Tat−/Meth brains. NS = not significant.
| Matrix | Factor Name | Sequence | Sites Tat−/Meth vs. Tat−/Sal (MSS) | Sites/Sequences Tat−/Meth vs. Tat−/Sal (CSS) | Sites Tat+/Meth vs. Tat−/Meth (MSS) | Sites/Sequences Tat+/Meth vs. Tat−/Meth (CSS) |
|---|---|---|---|---|---|---|
| V$CPBP_Q6 | KLF6 |
|
117 | 5.57 | 1627 | 3.86 |
| V$TATA_01 | TBP-related factors |
|
NS | NS | 156 | 2.82 |
| V$BCL6_Q3_01 | BCL-6 factors |
|
3 | 3.00 | NS | NS |
| V$ZNF333_01 | ZNF333 |
|
25 | 2.50 | 369 | 1.84 |
| V$MAZ_Q6_01 | MAZ |
|
10 | 2.50 | NS | NS |
| V$SRY_Q6 | Sox-related factors |
|
NS | NS | 330 | 1.95 |
| V$AP1_03 | AP-1 (JUN/FOS) |
|
24 | 2.40 | 198 | 2.28 |
| V$ZFP161_04 | ZFP161 |
|
21 | 2.33 | NS | NS |
| V$SP1_Q6_01 | Sp1 group |
|
16 | 2.29 | NS | NS |
| V$BEN_01 | BEN |
|
29 | 2.23 | NS | NS |
| V$NR3C1_03 | GR-like receptors |
|
8 | 2.00 | NS | NS |
| V$CREBP1_01 | ATF-2 group |
|
2 | 2.00 | 145 | 2.07 |
| V$P53_04 | TP53 |
|
4 | 2.00 | 128 | 1.97 |
| V$MYOGENIN_Q6_01 | MYOD1 |
|
14 | 2.00 | 398 | 2.57 |
| V$BBX_03 | Bbx |
|
NS | NS | 11 | 1.83 |