Table 1.
Murine models of C. jejuni infection applying conventional and microbiota depleted wildtype mice.
Mouse Strain | Intestinal Microbiota | Antibiotic Treatment/Specific Diet | Intestinal Colonization of C. jejuni | LOS Sensitized | Macroscopic Signs of Disease | Inflammatory Responses | Reference |
---|---|---|---|---|---|---|---|
C57BL/6 | SPF | No/No | Low | No | No | Elevated T-helper-1 cell responses in intestinal compartments | [56] |
C57BL/6 | SPF | No/No | No | No | No | Intestinal epithelial cell apoptosis and proliferation/regeneration, moderate cellular and molecular inflammatory responses | [46] |
C57BL/6 | No-SA | Yes/No | High | No | No | Intestinal epithelial cell apoptosis and proliferation/regeneration, pronounced cellular and molecular inflammatory responses | [46] |
C57BL/6 | SA plus rHF | Yes/No | Moderate | No | No | Intestinal epithelial cell apoptosis and proliferation/regeneration, pronounced cellular and molecular inflammatory responses | [46] |
BALB/c Neonatal | SPF | No/No | Moderate | Yes | Wasting, bloody diarrhea | ND | [57] |
C57BL/6 Infant | SPF | No/No | Moderate | Yes | Wasting, bloody diarrhea (self-limiting) | Intestinal epithelial cell apoptosis and proliferation/regeneration, elevated pro-inflammatory mediators, extra-intestinal T cell infiltrates | [58] |
C57BL/6 Zinc deficient |
Depleted | Yes/Zinc depleted | High | Yes | Wasting, bloody diarrhea | Intestinal edema, pronounced neutrophilic infiltration, crypt hyperplasia, intestinal and systemic inflammatory mediator responses | [53] |
ND, not determined; SA, secondary abiotic; rHF, recolonized with human microbiota; SPF, specific pathogen-free murine microbiota.