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. 2020 Mar 28;8(4):482. doi: 10.3390/microorganisms8040482

Table 1.

Murine models of C. jejuni infection applying conventional and microbiota depleted wildtype mice.

Mouse Strain Intestinal Microbiota Antibiotic Treatment/Specific Diet Intestinal Colonization of C. jejuni LOS Sensitized Macroscopic Signs of Disease Inflammatory Responses Reference
C57BL/6 SPF No/No Low No No Elevated T-helper-1 cell responses in intestinal compartments [56]
C57BL/6 SPF No/No No No No Intestinal epithelial cell apoptosis and proliferation/regeneration, moderate cellular and molecular inflammatory responses [46]
C57BL/6 No-SA Yes/No High No No Intestinal epithelial cell apoptosis and proliferation/regeneration, pronounced cellular and molecular inflammatory responses [46]
C57BL/6 SA plus rHF Yes/No Moderate No No Intestinal epithelial cell apoptosis and proliferation/regeneration, pronounced cellular and molecular inflammatory responses [46]
BALB/c Neonatal SPF No/No Moderate Yes Wasting, bloody diarrhea ND [57]
C57BL/6 Infant SPF No/No Moderate Yes Wasting, bloody diarrhea (self-limiting) Intestinal epithelial cell apoptosis and proliferation/regeneration, elevated pro-inflammatory mediators, extra-intestinal T cell infiltrates [58]
C57BL/6
Zinc deficient
Depleted Yes/Zinc depleted High Yes Wasting, bloody diarrhea Intestinal edema, pronounced neutrophilic infiltration, crypt hyperplasia, intestinal and systemic inflammatory mediator responses [53]

ND, not determined; SA, secondary abiotic; rHF, recolonized with human microbiota; SPF, specific pathogen-free murine microbiota.