Table 3.
Percentage change in protein-bound uremic plasma concentrations over time in patients treated with hemodialysis and hemodiafiltration stratified for patients with and without residual kidney function.
| PBUT | RKF | HD | HDF | HD vs. HDF | ||||
|---|---|---|---|---|---|---|---|---|
| N | ∆ (% Change/6 Months) | p* | N | ∆ (% Change/6 Months) | p* | p** | ||
| Kynurenine | all | 38 | −7.7 (−22.6 to 14.5) | 0.269 | 35 | −5.9 (−20.9 to 29.3) | 0.694 | 0.453 |
| NO | 19 | −9.4 (−21.8 to 12.4) | 0.171 | 12 | −19.6 (−42.2 to 5.6) | 0.019 | 0.181 | |
| YES | 19 | −5.9 (−30.1 to 25.7) | 0.693 | 23 | 17.6 (−13.5 to 17.5) | 0.226 | 0.146 | |
| Kynurenic acid | all | 38 | 5.6 (−8.6 to 69.1) | 0.111 | 36 | 3.2 (−22.1 to 39.5) | 0.537 | 0.430 |
| NO | 19 | 10.0 (−8.5 to 68.8) | 0.414 | 12 | −6.1 (−35.2 to 28.5) | 0.729 | 0.256 | |
| YES | 19 | 1.6 (−9.1 to 70.1) | 0.141 | 24 | 12.8 (−14.0 to 43.8) | 0.150 | 0.883 | |
| Indoxyl sulfate | all | 38 | 11.9 (−15.4 to 31.9) | 0.133 | 36 | −8.0 (−34.6 to 15.3) | 0.092 | 0.045 |
| NO | 19 | 14.5 (−14.3 to 31.7) | 0.130 | 12 | 4.6 (−19.6 to 19.6) | 0.992 | 0.351 | |
| YES | 19 | 1.7 (−21.3 to 33.9) | 0.524 | 24 | −17.8 (−48.0 to 10.9) | 0.075 | 0.129 | |
| Indole-3-acetic acid | all | 25 | 9.2 (−19.6 to 34.9) | 0.876 | 27 | −10.8 (−26.0 to 14.0) | 0.615 | 0.356 |
| NO | 12 | 0.6 (−36.3 to 25.9) | 0.721 | 10 | −15.1 (−28.3 to 5.3) | 0.314 | 0.568 | |
| YES | 13 | 10.9 (−15.2 to 40.7) | 0.477 | 17 | 5.8 (−25.6 to 52.5) | 0.861 | 0.434 | |
| p-Cresyl sulfate | all | 38 | −8.8 (−28.9 to 29.5) | 0.510 | 36 | −2.7 (−27.4 to 10.2) | 0.199 | 0.854 |
| NO | 19 | −7.3 (−24.2 to 17.6) | 0.381 | 12 | 2.6 (−21.7 to 86.9) | 0.859 | 0.394 | |
| YES | 19 | −10.7 (−31.8 to 79.5) | 0.906 | 24 | −4.0 (−40.3 to 0.00) | 0.053 | 0.477 | |
| p-Cresyl glucuronide | all | 38 | −7.0 (−38.1 to 69.8) | 0.421 | 36 | 7.4 (−37.3 to 65.3) | 0.765 | 0.681 |
| NO | 19 | −6.4 (−43.6 to 39.2) | 0.077 | 12 | 30.5 (−33.5 to 181.0) | 0.239 | 0.096 | |
| YES | 19 | −15.5 (−36.6 to 154.6) | 0.520 | 24 | −2.8 (−53.5 to 50.0) | 0.710 | 0.478 | |
| Hippuric acid | all | 38 | 5.7 (−44.6 to 54.5) | 0.531 | 36 | −21.9 (−47.6 to 42.4) | 0.187 | 0.566 |
| NO | 19 | 11.1 (−42.6 to 59.9) | 0.557 | 12 | −11.1 (−47.5 to 75.3) | 0.583 | 0.832 | |
| YES | 19 | 5.7 (−47.7 to 53.1) | 0.778 | 24 | −29.6 (−47.6 to 42.4) | 0.199 | 0.696 | |
Data are presented as median (interquartile range). * P values were calculated comparing plasma concentrations at baseline vs. 6 months using a Students paired t-test or Wilcoxon signed rank test as appropriate. ** P values were calculated using a Mann-Whitney U test, significant p-values are shown in bold font. HD, low-flux hemodialysis; HDF, hemodiafiltration; PBUT, protein-bound uremic toxin; RKF, residual kidney function; ∆, percentage change in PBUT plasma concentrations from baseline to 6-months of follow-up (% change/6 months).