Table 5.

Hazard ratios for all-cause mortality and new cardiovascular events for PBUT plasma concentrations at baseline.

				Hazard Ratio (95% CI)
PBUT	Outcome	N	# Events	Model I	P	Model II	P
Kynurenine (µmol/L)	All-cause mortality	79	34	1.020 (0.802 to 1.298)	0.872	0.943 (0.707 to 1.256)	0.687
	CV events	78	29	1.054 (0.807 to 1.376)	0.701	0.982 (0.717 to 1.346)	0.911
Kynurenic acid (µmol/L)	All-cause mortality	80	35	0.879 (0.638 to 1.210)	0.429	1.104 (0.666 to 1.829)	0.702
	CV events	79	29	0.876 (0.622 to 1.235)	0.876	1.333 (0.798 to 2.226)	0.272
Indoxyl sulfate (µmol/L)	All-cause mortality	80	35	1.001 (0.995 to 1.006)	0.837	1.002 (0.995 to 1.009)	0.617
	CV events	79	29	1.003 (0.998 to 1.008)	0.290	1.007 (1.000 to 1.015)	0.056
Indole-3-acetic acid (µmol/L)	All-cause mortality	60	24	1.190 (0.609 to 2.323)	0.610	1.346 (0.568 to 3.192)	0.500
	CV events	59	20	1.002 (0.493 to 2.039)	0.995	1.434 (0.535 to 3.847)	0.474
p-Cresyl sulfate (µmol/L)	All-cause mortality	80	35	0.955 (0.670 to 1.362)	0.801	0.897 (0.614 to 1.310)	0.574
	CV events	79	29	0.960 (0.664 to 1.389)	0.829	1.036 (0.667 to 1.611)	0.874
p-Cresyl glucuronide (µmol/L)	All-cause mortality	80	35	0.992 (0.767 to 1.283)	0.952	1.024 (0.782 to 1.340)	0.864
	CV events	79	29	1.032 (0.775 to 1.374)	0.830	1.189 (0.863 to 1.636)	0.289
Hippuric acid (µmol/L)	All-cause mortality	78	33	1.037 (0.688 to 1.562)	0.862	0.966 (0.569 to 1.642)	0.900
	CV events	77	28	0.722 (0.457 to 1.142)	0.164	0.823 (0.445 to 1.524)	0.536

Uni/Multivariate Cox proportional hazards regression analysis censored for kidney transplantation. Model I: univariate; model II: adjustment for age, gender, diabetes mellitus, history of cardiovascular disease, renal creatinine clearance and normalized protein nitrogen appearance. Data are expressed as hazard ratios with 95% confidence interval (CI) and p-value for the occurrence of new cardiovascular (CV) events and all-cause mortality associated with a one-unit increase in PBUT plasma concentration.