Table 2.
Minimum inhibitory concentration (MIC) (μg/mL) and minimum bactericidal concentration (MBC) (μg/mL) values of PD, DFZ and its precursors against a panel of Gram-negative and Gram-positive pathogens.
| Bacteria | Compound | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PYED-1 | 2 (DFZ) | 3 | 4 | 5 | 6 | 7 | 8 (PD) | |||||||||
| MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | |
|
Staphylococcus aureus ATCC 29213 |
16 | 16 | >1000 | >1000 | 375 | >1000 | >1000 | >1000 | 750 | >1000 | 256 | 512 | 1000 | 1000 | >1000 | >1000 |
|
Enterococcus faecalis ATCC 29212 |
4 | 16 | >1000 | >1000 | 187 | >1000 | >1000 | >1000 | 375 | >1000 | 128 | 256 | 1000 | 1000 | >1000 | >1000 |
|
Acinetobacter baumannii ATCC 17978 |
16 | 16 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | 512 | 512 | 1000 | 1000 | >1000 | >1000 |
|
Pseudomonas aeruginosa ATCC 27859 |
128 | 1000 | >1000 | >1000 | 750 | >1000 | >1000 | >1000 | >1000 | >1000 | 1000 | 1000 | 1000 | 1000 | >1000 | >1000 |
|
Escherichia coli ATCC 25922 |
128 | 128 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | 1000 | 1000 | 1000 | 1000 | >1000 | >1000 |
|
Klebsiella pneumoniae ATCC 700603 |
>1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 |
|
Enterobacter aerogenes ATCC 13048 |
>1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 |