Table 3.

The free energies calculated from MD simulations for the RBD proteins of SARS-CoV-2 and SARS-CoV, where $G_{\mathrm{gas}}$ is the interaction energy in the gas and $G_{\mathrm{solv}}$ is the solvation energy in the solvent, respectively. All units are reported in kcal/mol. The t-test was conducted to check the statistical significance of the difference between two sets of free energies. A p-value of <0.05 indicates that the difference is statistically significant (95% confidence interval).

	SARS-CoV-2		SARS-CoV		T-Test
	Average	Std. Dev.	Average	Std. Dev.	Difference	p-Value
$G_{\mathrm{gas}}$	−2104.3687	72.3143	−1703.6586	75.9595	−400.7101	<0.0001
$G_{\mathrm{solv}}$	−1985.6759	51.4409	−1914.0726	56.7862	−71.6033	<0.0001
$G_{\mathrm{total}}$	−4090.0446	40.6600	−3617.7312	38.9307	−472.3134	<0.0001