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. 2020 May 6;11:648. doi: 10.3389/fimmu.2020.00648

Figure 3.

Figure 3

Soluble factors in the crosstalk between keratinocytes and fibroblasts. (A) IL-1 and KGF are soluble mediators robustly identified as involved in the crosstalk. (B) Autocrine and paracrine effects relevant to IL-1 and KGF role in the crosstalk. (C) The many effects of keratinocyte produced IL-1 on fibroblasts. (D) Synergistic effect of IL-1 with IL-6 family members (in red) on the crosstalk. Arrowheads indicate enhancement. bFGF, basic fibroblast growth factor; COX2, Cyclooxygenase 2; CXCL, chemokine containing the CXC motif; EGF, epidermal growth factor which comprises multiple mediators including transforming growth factor-α, amphiregulin, heparin binding-EGF, and epiregulin; ENA-78, Epithelial neutrophil-activating protein 78; FGF, fibroblast growth factor; GM-CSF, granulocyte-monocyte colony stimulating factor IL, interleukin; KGF, keratinocyte growth factor (also known as FGF7); LIF, leukemia inhibitory factor; MCP-1, monocyte chemotactic protein-1; OSM, oncostatin M;PGE2, Prostaglandin E2; TGF, Transforming growth factor; VEGF, vascular endothelial growth factor.