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. 2020 May 5;8:298. doi: 10.3389/fcell.2020.00298

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Copyright © 2020 Tripisciano, Weiss, Karuthedom George, Fischer and Weber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of soluble proteins co-enriched during isolation of extracellular vesicles on thrombin generation. (A) EVs isolated from medical grade platelet concentrates (pEVs) and (B) from red blood cell concentrates (rbcEVs) were separated from soluble co-enriched proteins by size exclusion chromatography (SEC), and EV-containing fractions were pooled and characterized as described in the section “Materials and Methods.” (C) EV counts (assessed by FC) normalized to protein content before and after size exclusion chromatography. (D) Thrombin generation induced by pEVs and rbcEVs before and after purification via size exclusion column chromatography (n = 3); ****p ≤ 0.0001.