Table 2.
Prognosis factors of recurrence-free survival and overall survival in the whole patients.
| Variables | Recurrence-free survival | Overall survival | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariable | Multivariable | Univariable | Multivariable | |||||
| Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | Hazard ratio (95%CI) | P-value | Hazard ratio (95% CI) | P-value | |
| Sex, male | 1.487 (1.135, 1.948) | 0.004 | 1.696 (1.285, 2.238) | <0.001 | 1.171 (0.777, 1.765) | 0.450 | ||
| Age, year | 1.000 (0.990, 1.009) | 0.941 | 1.020 (1.005, 1.035) | 0.010 | ||||
| TBIL, μmol/L | 1.009 (0.995, 1.023) | 0.197 | 1.014 (0.991, 1.037) | 0.231 | ||||
| TP, g/L | 0.968 (0.951, 0.984) | <0.001 | 0.973 (0.947, 0.999) | 0.043 | ||||
| ALB, g/L | 0.926 (0.903, 0.949) | <0.001 | 0.955 (0.929, 0.982) | 0.001 | 0.897 (0.862, 0.932) | <0.001 | ||
| ALT, U/L | 1.005 (1.003, 1.008) | <0.001 | 1.001 (0.995, 1.006) | 0.852 | ||||
| AST, U/L | 1.012 (1.007, 1.016) | <0.001 | 1.006 (1.002, 1.011) | 0.010 | 1.009 (1.002, 1.016) | 0.008 | ||
| GGT, U/L | 1.003 (1.002, 1.004) | <0.001 | 1.001 (1.000, 1.002) | 0.042 | 1.003 (1.001, 1.004) | <0.001 | 1.002 (1.000, 1.003) | 0.026 |
| ALP, U/L | 1.006 (1.002, 1.010) | 0.002 | 1.011 (1.006, 1.017) | <0.001 | ||||
| AFP, ng/mL | 1.000 (1.000, 1.000) | 0.285 | 1.000 (1.000, 1.001) | 0.149 | ||||
| CA199, ng/mL | 1.004 (1.000, 1.008) | 0.036 | 1.005 (0.999, 1.011) | 0.107 | ||||
| WBC, ×109/L | 0.932 (0.879, 0.988) | 0.019 | 0.965 (0.879, 1.060) | 0.456 | ||||
| RBC, ×109/L | 0.896 (0.744, 1.081) | 0.252 | 0.577 (0.435, 0.765) | <0.001 | ||||
| PLT, ×109/L | 0.997 (0.995, 0.998) | <0.001 | 0.997 (0.994, 0.999) | 0.017 | ||||
| INR | 33.181 (11.210, 98.218) | <0.001 | 28.473 (5.268, 153.890) | <0.001 | ||||
| PT, s | 1.339 (1.224, 1.466) | <0.001 | 1.181 (1.069, 1.304) | 0.001 | 1.326 (1.152, 1.525) | <0.001 | ||
| HBsAg, positive | 1.149 (0.831, 1.590) | 0.401 | 0.638 (0.414, 0.981) | 0.040 | ||||
| HBsAb, positive | 0.928 (0.707, 1.218) | 0.590 | 1.113 (0.739, 1.677) | 0.609 | ||||
| HBeAg, positive | 1.261 (1.036, 1.534) | 0.020 | 1.220 (0.893, 1.666) | 0.211 | ||||
| HBeAb, positive | 0.939 (0.761, 1.159) | 0.560 | 0.818 (0.589, 1.134) | 0.228 | ||||
| HBcAb, positive | 1.886 (0.470, 7.565) | 0.371 | 0.444 (0.142, 1.390) | 0.163 | ||||
| HBV DNA load, >103 IU/mL | 1.336 (1.108, 1.610) | 0.002 | 1.192 (0.886, 1.603) | 0.246 | ||||
| Child–Pugh, B | 1.912 (1.122, 3.257) | 0.017 | 2.042 (0.904, 4.611) | 0.086 | ||||
| Hepatectomy, anatomical | 0.814 (0.620, 1.068) | 0.138 | 0.758 (0.480, 1.195) | 0.233 | ||||
| Transfusion, yes | 1.233 (0.938, 1.622) | 0.134 | 1.306 (0.855, 1.994) | 0.217 | ||||
| Pringle maneuver, yes | 0.996 (0.767, 1.294) | 0.977 | 1.012 (0.668, 1.535) | 0.954 | ||||
| Diameter, cm | 1.101 (1.006, 1.204) | 0.036 | 1.304 (1.128, 1.506) | <0.001 | 1.279 (1.103, 1.483) | 0.001 | ||
| Cirrhosis, yes | 1.511 (1.237, 1.845) | <0.001 | 1.727 (1.239, 2.407) | <0.001 | 1.529 (1.085, 2.155) | 0.015 | ||
| Capsule, no | 1.161 (0.894, 1.507) | 0.264 | 1.529 (1.052, 2.223) | 0.026 | ||||
| MVI, yes | 1.506 (1.249, 1.816) | <0.001 | 1.667 (1.378, 2.017) | <0.001 | 2.369 (1.759, 3.192) | <0.001 | 2.578 (1.905, 3.488) | <0.001 |
| ES grade, III–IV | 1.046 (0.859, 1.274) | 0.654 | 1.754 (1.237, 2.489) | 0.002 | ||||
| Surgical margin, narrow | 1.795 (1.487, 2.168) | <0.001 | 1.781 (1.469, 2.160) | <0.001 | 1.924 (1.418, 2.611) | <0.001 | 1.935 (1.413, 2.650) | <0.001 |
TBIL, total bilirubin; TP, total protein; ALB, albumin; ALT, alanine transaminase; AST, aspartate aminotransferase; GGT, γ-glutamyl transpeptidase; ALP, alkaline phosphatase; AFP, α fetal protein; CA199, carbohydrate antigen 19-9; WBC, white blood cells; RBC, red blood cells; PLT, platelets; INR, international normalized ratio; PT, prothrombin time; HBsAg, hepatitis B surface antigen; HBsAb, hepatitis B surface antibody; HBeAg, hepatitis B e antigen; HBeAb, hepatitis B e antibody; HBcAb, hepatitis B c antibody; HBV DNA, hepatitis B virus deoxyribonucleic acid; MVI, microvascular invasion; ES, Edmondson–Steiner.