Table 3.
Prognosis factors of early and late recurrence in the whole patients.
| Variables | Early recurrence-free survival | Late recurrence-free survival | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariable | Multivariable | Univariable | Multivariable | |||||
| Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | |
| Sex, male | 1.730 (1.210, 2.474) | 0.003 | 1.177 (0.777, 1.783) | 0.443 | ||||
| Age, year | 0.994 (0.983, 1.005) | 0.299 | 1.011 (0.995, 1.027) | 0.194 | ||||
| TBIL, μmol/L | 1.010 (0.994, 1.026) | 0.211 | 1.006 (0.979, 1.035) | 0.661 | ||||
| TP, g/L | 0.955 (0.935, 0.976) | <0.001 | 0.991 (0.963, 1.020) | 0.541 | ||||
| ALB, g/L | 0.919 (0.891, 0.947) | <0.001 | 0.940 (0.900, 0.982) | 0.005 | ||||
| ALT, U/L | 1.006 (1.003, 1.009) | <0.001 | 1.004 (0.999, 1.009) | 0.098 | ||||
| AST, U/L | 1.011 (1.006, 1.016) | <0.001 | 1.008 (1.003, 1.013) | 0.002 | 1.013 (1.006, 1.021) | <0.001 | ||
| GGT, U/L | 1.003 (1.002, 1.004) | <0.001 | 1.003 (1.001, 1.005) | 0.003 | 1.003 (1.001, 1.005) | 0.014 | ||
| ALP, U/L | 1.006 (1.001, 1.010) | 0.012 | 1.006 (1.000, 1.013) | 0.054 | ||||
| AFP, ng/mL | 1.001 (1.000, 1.001) | <0.001 | 1.000 (1.000, 1.001) | 0.002 | 0.999 (0.998, 0.999) | <0.001 | ||
| CA199, ng/mL | 1.004 (0.999, 1.008) | 0.162 | 1.006 (0.999, 1.013) | 0.096 | ||||
| WBC, ×109/L | 0.939 (0.873, 1.009) | 0.087 | 0.918 (0.830, 1.016) | 0.100 | ||||
| RBC, ×109/L | 0.934 (0.743, 1.175) | 0.561 | 0.824 (0.596, 1.140) | 0.242 | ||||
| PLT, ×109/L | 0.998 (0.996, 1.000) | 0.057 | 0.994 (0.991, 0.996) | <0.001 | ||||
| INR | 40.520 (10.818, 151.766) | <0.001 | 22.048 (3.270, 148.652) | 0.001 | ||||
| PT, s | 1.362 (1.221, 1.520) | <0.001 | 1.293 (1.104, 1.515) | 0.001 | ||||
| HBsAg, positive | 1.262 (0.831, 1.917) | 0.274 | 0.980 (0.584, 1.644) | 0.937 | ||||
| HBsAb, positive | 0.776 (0.540, 1.115) | 0.171 | 1.222 (0.806, 1.851) | 0.345 | ||||
| HBeAg, positive | 1.152 (0.902, 1.471) | 0.258 | 1.494 (1.076, 2.075) | 0.017 | ||||
| HBeAb, positive | 1.071 (0.819, 1.399) | 0.617 | 0.744 (0.528, 1.048) | 0.091 | ||||
| HBcAb, positive | 2.480 (0.348, 17.668) | 0.364 | 1.292 (0.181, 9.233) | 0.798 | ||||
| HBV DNA load, >103 IU/mL | 1.440 (1.142, 1.817) | 0.002 | 1.328 (1.045, 1.687) | 0.021 | 1.161 (0.846, 1.592) | 0.355 | ||
| Child–Pugh, B | 1.497 (0.741, 3.024) | 0.260 | 3.015 (1.332, 6.829) | 0.008 | 2.622 (1.151, 5.971) | 0.022 | ||
| Hepatectomy, anatomical | 0.878 (0.631, 1.221) | 0.438 | 0.703 (0.435, 1.136) | 0.150 | ||||
| Transfusion, yes | 1.273 (0.915, 1.771) | 0.152 | 1.153 (0.705, 1.885) | 0.571 | ||||
| Pringle maneuver, yes | 0.821 (0.607, 1.111) | 0.201 | 1.590 (0.933, 2.708) | 0.088 | ||||
| Diameter, cm | 1.213 (1.085, 1.356) | 0.001 | 0.920 (0.790, 1.071) | 0.282 | ||||
| Cirrhosis, yes | 1.439 (1.124, 1.844) | 0.004 | 1.650 (1.175, 2.317) | 0.004 | 1.518 (1.075, 2.145) | 0.018 | ||
| Capsule, no | 1.417 (1.048, 1.917) | 0.024 | 1.361 (1.000, 1.852) | 0.050 | 0.718 (0.421, 1.223) | 0.223 | ||
| MVI, yes | 1.916 (1.523, 2.411) | <0.001 | 1.923 (1.520, 2.433) | <0.001 | 0.915 (0.648, 1.292) | 0.613 | ||
| ES grade, III–IV | 1.196 (0.931, 1.536) | 0.161 | 0.825 (0.597, 1.140) | 0.244 | ||||
| Surgical margin, narrow | 1.786 (1.413, 2.258) | <0.001 | 1.925 (1.519, 2.440) | <0.001 | 1.812 (1.319, 2.490) | <0.001 | ||
TBIL, total bilirubin; TP, total protein; ALB, albumin; ALT, alanine transaminase; AST, aspartate aminotransferase; GGT, γ-glutamyl transpeptidase; ALP, alkaline phosphatase; AFP, α fetal protein; CA199, carbohydrate antigen 19-9; WBC, white blood cells; RBC, red blood cells; PLT, platelets; INR, international normalized ratio; PT, prothrombin time; HBsAg, hepatitis B surface antigen; HBsAb, hepatitis B surface antibody; HBeAg, hepatitis B e antigen; HBeAb, hepatitis B e antibody; HBcAb, hepatitis B c antibody; HBV DNA, hepatitis B virus deoxyribonucleic acid; MVI, microvascular invasion; ES, Edmondson–Steiner.