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. 2020 May 8;11:357. doi: 10.3389/fgene.2020.00357

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Copyright © 2020 Deng, Li, Wang, Geng, Cai, Tang, Wang, Yu, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of circ_0001946 inhibits the proliferation of colorectal cancer (CRC) cells. (A) The expression of circ_0001946 in CRC cell lines (LoVo, SW480, Caco-2, SW620, and HT-29) and immortalized normal intestinal cell line FHC. (B) Successful construction of circ_0001946-downregulated LoVo cells by a lentivirus-based method. (C) Successful construction of circ_0001946-downregulated SW480 cells by a lentivirus-based method. (D) The proliferation of circ_0001946-downregulated LoVo cells, as measured by the Cell Counting Kit-8 (CCK-8) assay. (E) The proliferation of circ_0001946-downregulated SW480 cells, as measured by the CCK-8 assay. All experiments were repeated at least three times. **P < 0.01, ***P < 0.001.